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Resveratrol
Grows
New
Capillaries
We
know
that
resveratrol
minimizes
negative
estrogen
effects
and
helps
maximize
natural
testosterone.
Turns
out,
it
does
even
more.
Everyone
knows
by
now
that
resveratrol
is
something
found
in
red
wine
and
that
it’s
somehow
related
to
healthy
aging.
If
you
really
know
your
stuff,
you
also
know
that
resveratrol
(Buy
at
Amazon)
is
anti-inflammatory,
testosterone-elevating,
and
aromatase-blocking
(it
helps
control
estrogen).
It’s
even
neuroprotective.
Now
we
know
that
resveratrol
does
something
else,
too:
It
situationally
facilitates
capillary
growth.
Who
Cares
About
Capillaries?
Resveratrol
has
vasodilation
properties,
meaning
it
“inflates”
blood
vessels,
thereby
lowering
blood
pressure
while
also
allowing
more
blood
flow.
It
does
this
through
four
key
mechanisms,
all
of
which
are
involved
in
the
activation
of
an
enzyme
called
endothelial
nitric
oxide
synthase
(eNOS),
which
leads
to
the
production
of
nitric
oxide
(NO).
It’s
this
NO
that
leads
to
blood
vessels
turning
into
a
four-lane
tunnel
instead
of
a
traffic-jammed
two-lane
tunnel.
This
is
good
because
bigger,
more
pliable
blood
vessels
equate
to
less
blood
clotting
and
reduced
blood
pressure,
less
plaque
formation,
and
strong
erections.
Resveratrol
does
something
else,
too.
It
helps
build
capillary
bridges
–
ladders,
if
you
will
–
to
reestablish
and
maintain
blood
flow
to
the
heart
when
arteries
need
a
little
help.
This
process
by
which
new
capillaries
grow
is
known
as
angiogenesis.
One
stunning
experiment
found
that
“preconditioning”
animals
with
resveratrol
(giving
it
to
them
before
intervention)
increased
the
number
of
capillaries
formed
around
their
blocked
coronary
arteries
in
as
little
as
three
weeks,
thus
supporting
heart
function.
It
did
this
by
increasing
levels
of
VEGF,
a
substance
made
by
cells
that
prompts
angiogenesis.
Forming
“Ladders”
to
Muscles
Too
Resveratrol
also
appears
to
build
capillary
ladders
to
muscle
cells,
at
least
in
animals.
By
doing
so,
it
makes
muscle
fibers
more
resistant
to
fatigue
and
more
“age
resistant”
in
general.
When
skeletal
muscles
age,
they’re
sometimes
plagued
by
“tubular
aggregates”
(TA),
which
are
defined
as
a
“subsarcolemmal
accumulation
of
granular
materials.”
One
theory
is
that
TAs
are
caused
by
injuries
(or
aging)
to
the
sarcoplasmic
reticulum
–
a
membrane
found
in
muscle
tissues
–
which
screws
up
the
calcium
flux:
the
reaction
that
enables
muscle
to
contract
and
relax.
All
those
TAs
lead
to
muscle
weakness,
but
experiments
with
rats
found
that
relatively
modest
amounts
of
resveratrol
(0.04%
of
diet)
led
to
an
enhanced
capillary
network
that
also
reduced
the
number
of
TAs.
This
enhanced
capillary
network
occurred
independent
of
muscle
fiber
type,
which
is
cool
because
normally,
type
IIB
fibers
(fast
twitch)
have
fewer
capillaries
to
begin
with.
This
is
significant
because
resistance
to
fatigue
is
positively
correlated
with
capillary
density.
The
more
capillaries,
the
longer
muscle
fibers
can
continue
to
fire.
An
Interesting
Note
Resveratrol
seems
rather
fickle
in
which
specific
capillaries
it
chooses
to
nurture.
For
instance,
it
seems
to
inhibit
capillary
growth
in
animal
tumors
while
it
increases
capillarization
around
the
heart
and,
in
at
least
one
experiment,
animal
muscle
fibers.
Why
it
has
this
fickle
nature
isn’t
clear.
It
may
well
be
that
the
resveratrol-induced
angiogenesis
occurs
mainly
in
older
people.
However,
other
experiments
have
shown
that
resveratrol
enhances
the
energy-producing
capability
of
mitochondria
(the
energy-producing
organelles
of
the
cell)
in
young
and
old
athletes,
which,
by
itself,
increases
exercise
endurance.
Get
the
Right
Amount
of
the
Right
Kind
Most
people
think
about
wine
when
they
think
about
resveratrol.
But
you’d
have
to
drink
about
140
bottles
to
get
an
effective
dose.
(Don’t
do
that.)
You
might
be
able
to
ingest
enough
resveratrol
from
a
combination
of
whole
foods
or
drinks
to
do
you
some
good,
but
you’d
have
to
eat
an
awful
lot
of
blueberries,
bilberries,
cranberries,
peanuts,
and
cocoa
and
do
it
consistently.
A
supplement
is
the
logical
choice.
It
usually
is
when
it
comes
to
polyphenols
and
carotenoids.
That’s
why
we
made
Rez-V
(Buy
at
Amazon).
Two
Rez-V
softgels
contain
600
mg
of
active
pure
trans-resveratrol,
the
type
and
amount
required
for
an
effective
dose.
References
Fukuda
S
et
al.
“Resveratrol
ameliorates
myocardial
damage
by
inducing
vascular
endothelial
growth
factor-angiogenesis
and
tyrosine
kinase
receptor
Flk-1.”
Cell
Biochem
Biophys.
2006;44(1):43-9.
PubMed
16456233.
Kaga
S
et
al.
“Resveratrol
enhances
neovascularization
in
the
infarcted
rat
myocardium
through
the
induction
of
thioredoxin-1,
heme
oxygenase-1
and
vascular
endothelial
growth
factor.”
J
Mol
Cell
Cardiol.
2005
Nov;39(5):813-22.
PubMed
16198371.
Toniolo
L
et
al.
“Long-term
resveratrol
treatment
improves
the
capillarization
in
the
skeletal
muscles
of
ageing
C57BL/6J
mice.”
Int
J
Food
Sci
Nutr.
2021
Feb;72(1):37-44.
PubMed
32449407.
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